Ontology highlight
ABSTRACT:
SUBMITTER: Penaloza-MacMaster P
PROVIDER: S-EPMC4382081 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20150101 6219
CD4 T cells promote innate and adaptive immune responses, but how vaccine-elicited CD4 T cells contribute to immune protection remains unclear. We evaluated whether induction of virus-specific CD4 T cells by vaccination would protect mice against infection with chronic lymphocytic choriomeningitis virus (LCMV). Immunization with vaccines that selectively induced CD4 T cell responses resulted in catastrophic inflammation and mortality after challenge with a persistent strain of LCMV. Immunopathol ...[more]