Ontology highlight
ABSTRACT:
SUBMITTER: Minton DR
PROVIDER: S-EPMC4382166 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150401 4
Hypoxia inducible factor 1 alpha (HIF1α) is a transcription factor that is frequently stabilized and active in human clear cell renal cell carcinoma (ccRCC). We have found that constitutively active HIF1α is sufficient to cause neoplastic transformation in a murine model of ccRCC termed the TRACK model. RNA sequencing (RNAseq) and untargeted metabolomics analyses of samples from TRACK kidneys demonstrate that HIF1α activates the transcription of genes that cause increased glucose uptake, glycoly ...[more]