Analyses of the transcriptome and metabolome demonstrate that HIF1? mediates altered tumor metabolism in clear cell renal cell carcinoma.
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ABSTRACT:
SUBMITTER: Minton DR
PROVIDER: S-EPMC4382166 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma.
Minton Denise R DR Fu Leiping L Chen Qiuying Q Robinson Brian D BD Gross Steven S SS Nanus David M DM Gudas Lorraine J LJ
PloS one 20150401 4
Hypoxia inducible factor 1 alpha (HIF1α) is a transcription factor that is frequently stabilized and active in human clear cell renal cell carcinoma (ccRCC). We have found that constitutively active HIF1α is sufficient to cause neoplastic transformation in a murine model of ccRCC termed the TRACK model. RNA sequencing (RNAseq) and untargeted metabolomics analyses of samples from TRACK kidneys demonstrate that HIF1α activates the transcription of genes that cause increased glucose uptake, glycoly ...[more]
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