Immune therapy for treating type 1 diabetes: challenging existing paradigms.
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ABSTRACT:
SUBMITTER: Skyler JS
PROVIDER: S-EPMC4382231 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Immune therapy for treating type 1 diabetes: challenging existing paradigms.
The Journal of clinical investigation 20141215 1
Patients with type 1 diabetes (T1D) rapidly lose β cell function and/or mass, leading to a life-long dependence on insulin therapy. β Cell destruction is mediated by aberrant immune responses; therefore, immune modulation has potential to ameliorate disease. While immune intervention in animal models of diabetes has shown promising results, treatment of patients with T1D with the same agents has not been as successful. In this issue of the JCI, Haller and colleagues present data from a small cli ...[more]
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