Ontology highlight
ABSTRACT:
SUBMITTER: Petersen N
PROVIDER: S-EPMC4382243 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Petersen Natalia N Reimann Frank F van Es Johan H JH van den Berg Bernard M BM Kroone Chantal C Pais Ramona R Jansen Erik E Clevers Hans H Gribble Fiona M FM de Koning Eelco J P EJ
The Journal of clinical investigation 20141215 1
Glucagon-like peptide-1-based (GLP-1-based) therapies improve glycemic control in patients with type 2 diabetes. While these agents augment insulin secretion, they do not mimic the physiological meal-related rise and fall of GLP-1 concentrations. Here, we tested the hypothesis that increasing the number of intestinal L cells, which produce GLP-1, is an alternative strategy to augment insulin responses and improve glucose tolerance. Blocking the NOTCH signaling pathway with the γ-secretase inhibi ...[more]