Ontology highlight
ABSTRACT:
SUBMITTER: Dogan MY
PROVIDER: S-EPMC4382375 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Dogan Merve Yusra MY Can Sinan S Cleary Frank B FB Purde Vedud V Yildiz Ahmet A
Cell reports 20150326 12
Kinesin-1 is a two-headed motor that takes processive 8-nm hand-over-hand steps and transports intracellular cargos toward the plus-end of microtubules. Processive motility requires a gating mechanism to coordinate the mechanochemical cycles of the two heads. Kinesin gating involves neck linker (NL), a short peptide that interconnects the heads, but it remains unclear whether gating is facilitated by the NL orientation or tension. Using optical trapping, we measured the force-dependent microtubu ...[more]