Reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder.

ABSTRACT:

Objective

The authors assessed the functioning of mesolimbic and striatal areas involved in reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder (OCD).

Method

Functional MRI blood-oxygen-level-dependent response was compared in 33 unmedicated adults with OCD and 33 healthy, age-matched comparison subjects during a reward-based learning task that required learning to use extramaze cues to navigate a virtual eight-arm radial maze to find hidden rewards. The groups were compared in their patterns of brain activation associated with reward-based spatial learning versus a control condition in which rewards were unexpected because they were allotted pseudorandomly to experimentally prevent learning.

Results

Both groups learned to navigate t

SUBMITTER: Marsh R 

PROVIDER: S-EPMC4382407 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature