Ontology highlight
ABSTRACT:
SUBMITTER: Damy T
PROVIDER: S-EPMC4382536 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Journal of cardiovascular translational research 20150306 2
A phase 2, open-label study in 21 patients with non-Val30Met and non-Val122Ile hereditary transthyretin amyloidosis showed that tafamidis (20 mg daily for 12 months) stabilized these transthyretin variants. We assessed cardiac amyloid infiltration and cardiac abnormalities in this same study population. At baseline, median age was 64.3 years, 11 patients were in NYHA class II, 13 had conduction abnormalities, 14 N-terminal pro-hormone brain natriuretic peptide concentrations >300 pg/ml, and 17 i ...[more]