Ontology highlight
ABSTRACT:
SUBMITTER: Schiro G
PROVIDER: S-EPMC4382692 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Schirò Giorgio G Fichou Yann Y Gallat Francois-Xavier FX Wood Kathleen K Gabel Frank F Moulin Martine M Härtlein Michael M Heyden Matthias M Colletier Jacques-Philippe JP Orecchini Andrea A Paciaroni Alessandro A Wuttke Joachim J Tobias Douglas J DJ Weik Martin M
Nature communications 20150316
Hydration water is the natural matrix of biological macromolecules and is essential for their activity in cells. The coupling between water and protein dynamics has been intensively studied, yet it remains controversial. Here we combine protein perdeuteration, neutron scattering and molecular dynamics simulations to explore the nature of hydration water motions at temperatures between 200 and 300 K, across the so-called protein dynamical transition, in the intrinsically disordered human protein ...[more]