Ontology highlight
ABSTRACT:
SUBMITTER: Nan H
PROVIDER: S-EPMC4382867 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Nan Hongmei H Hutter Carolyn M CM Lin Yi Y Jacobs Eric J EJ Ulrich Cornelia M CM White Emily E Baron John A JA Berndt Sonja I SI Brenner Hermann H Butterbach Katja K Caan Bette J BJ Campbell Peter T PT Carlson Christopher S CS Casey Graham G Chang-Claude Jenny J Chanock Stephen J SJ Cotterchio Michelle M Duggan David D Figueiredo Jane C JC Fuchs Charles S CS Giovannucci Edward L EL Gong Jian J Haile Robert W RW Harrison Tabitha A TA Hayes Richard B RB Hoffmeister Michael M Hopper John L JL Hudson Thomas J TJ Jenkins Mark A MA Jiao Shuo S Lindor Noralane M NM Lemire Mathieu M Le Marchand Loic L Newcomb Polly A PA Ogino Shuji S Pflugeisen Bethann M BM Potter John D JD Qu Conghui C Rosse Stephanie A SA Rudolph Anja A Schoen Robert E RE Schumacher Fredrick R FR Seminara Daniela D Slattery Martha L ML Thibodeau Stephen N SN Thomas Fridtjof F Thornquist Mark M Warnick Greg S GS Zanke Brent W BW Gauderman W James WJ Peters Ulrike U Hsu Li L Chan Andrew T AT
JAMA 20150301 11
<h4>Importance</h4>Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer.<h4>Objective</h4>To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between regular use of aspirin and/or NSAIDs and single-nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.<h4>Design, setting, and participants</h4>Case-control stud ...[more]