Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution.
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ABSTRACT:
SUBMITTER: Kovac M
PROVIDER: S-EPMC4383019 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution.
Kovac Michal M Navas Carolina C Horswell Stuart S Salm Max M Bardella Chiara C Rowan Andrew A Stares Mark M Castro-Giner Francesc F Fisher Rosalie R de Bruin Elza C EC Kovacova Monika M Gorman Maggie M Makino Seiko S Williams Jennet J Jaeger Emma E Jones Angela A Howarth Kimberley K Larkin James J Pickering Lisa L Gore Martin M Nicol David L DL Hazell Steven S Stamp Gordon G O'Brien Tim T Challacombe Ben B Matthews Nik N Phillimore Benjamin B Begum Sharmin S Rabinowitz Adam A Varela Ignacio I Chandra Ashish A Horsfield Catherine C Polson Alexander A Tran Maxine M Bhatt Rupesh R Terracciano Luigi L Eppenberger-Castori Serenella S Protheroe Andrew A Maher Eamonn E El Bahrawy Mona M Fleming Stewart S Ratcliffe Peter P Heinimann Karl K Swanton Charles C Tomlinson Ian I
Nature communications 20150319
Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behaviour. Here we sequence the genomes or exomes of 31 pRCCs, and in four tumours, multi-region sequencing is undertaken. We identify BAP1, SETD2, ARID2 and Nrf2 pathway genes (KEAP1, NHE2L2 and CUL3) as probable drivers, together with at least eight other possible drivers. However, only ~10% of tumours harbour detectable pathogenic changes i ...[more]
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