Ontology highlight
ABSTRACT:
SUBMITTER: Torrent J
PROVIDER: S-EPMC4383067 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Torrent Joan J Vilchez-Acosta Alba A Muñoz-Torrero Diego D Trovaslet Marie M Nachon Florian F Chatonnet Arnaud A Grznarova Katarina K Acquatella-Tran Van Ba Isabelle I Le Goffic Ronan R Herzog Laetitia L Béringue Vincent V Rezaei Human H
Acta neuropathologica communications 20150403
<h4>Introduction</h4>The prion protein (PrP) binds to various molecular partners, but little is known about their potential impact on the pathogenesis of prion diseases<h4>Results</h4>Here, we show that PrP can interact in vitro with acetylcholinesterase (AChE), a key protein of the cholinergic system in neural and non-neural tissues. This heterologous association induced aggregation of monomeric PrP and modified the structural properties of PrP amyloid fibrils. Following its recruitment into Pr ...[more]