Ontology highlight
ABSTRACT:
SUBMITTER: Ly T
PROVIDER: S-EPMC4383314 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Ly Tony T Endo Aki A Lamond Angus I AI
eLife 20150102
Previously, we analyzed protein abundance changes across a 'minimally perturbed' cell cycle by using centrifugal elutriation to differentially enrich distinct cell cycle phases in human NB4 cells (Ly et al., 2014). In this study, we compare data from elutriated cells with NB4 cells arrested at comparable phases using serum starvation, hydroxyurea, or RO-3306. While elutriated and arrested cells have similar patterns of DNA content and cyclin expression, a large fraction of the proteome changes d ...[more]