Ontology highlight
ABSTRACT:
SUBMITTER: Neskey DM
PROVIDER: S-EPMC4383697 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Neskey David M DM Osman Abdullah A AA Ow Thomas J TJ Katsonis Panagiotis P McDonald Thomas T Hicks Stephanie C SC Hsu Teng-Kuei TK Pickering Curtis R CR Ward Alexandra A Patel Ameeta A Yordy John S JS Skinner Heath D HD Giri Uma U Sano Daisuke D Story Michael D MD Beadle Beth M BM El-Naggar Adel K AK Kies Merrill S MS William William N WN Caulin Carlos C Frederick Mitchell M Kimmel Marek M Myers Jeffrey N JN Lichtarge Olivier O
Cancer research 20150129 7
TP53 is the most frequently altered gene in head and neck squamous cell carcinoma, with mutations occurring in over two-thirds of cases, but the prognostic significance of these mutations remains elusive. In the current study, we evaluated a novel computational approach termed evolutionary action (EAp53) to stratify patients with tumors harboring TP53 mutations as high or low risk, and validated this system in both in vivo and in vitro models. Patients with high-risk TP53 mutations had the poore ...[more]