Dietary microbes modulate transgenerational cancer risk.
Ontology highlight
ABSTRACT:
SUBMITTER: Poutahidis T
PROVIDER: S-EPMC4383701 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Dietary microbes modulate transgenerational cancer risk.
Poutahidis Theofilos T Varian Bernard J BJ Levkovich Tatiana T Lakritz Jessica R JR Mirabal Sheyla S Kwok Caitlin C Ibrahim Yassin M YM Kearney Sean M SM Chatzigiagkos Antonis A Alm Eric J EJ Erdman Susan E SE
Cancer research 20150225 7
Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary exposures, leading to high rates of obesity and frequent cancers of lung and liver in two subsequent generations of mice. Transgenerational effects were transplantable using diet-associated bacteria commun ...[more]
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