Ontology highlight
ABSTRACT:
SUBMITTER: Flood VH
PROVIDER: S-EPMC4383803 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Flood Veronica H VH Schlauderaff Abraham C AC Haberichter Sandra L SL Slobodianuk Tricia L TL Jacobi Paula M PM Bellissimo Daniel B DB Christopherson Pamela A PA Friedman Kenneth D KD Gill Joan Cox JC Hoffmann Raymond G RG Montgomery Robert R RR
Blood 20150206 14
Von Willebrand factor (VWF) contains binding sites for platelets and for vascular collagens to facilitate clot formation at sites of injury. Although previous work has shown that VWF can bind type IV collagen (collagen 4), little characterization of this interaction has been performed. We examined the binding of VWF to collagen 4 in vitro and extended this characterization to a murine model of defective VWF-collagen 4 interactions. The interactions of VWF and collagen 4 were further studied usin ...[more]