Ontology highlight
ABSTRACT:
SUBMITTER: Biagioli M
PROVIDER: S-EPMC4383859 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Biagioli Marta M Ferrari Francesco F Mendenhall Eric M EM Zhang Yijing Y Erdin Serkan S Vijayvargia Ravi R Vallabh Sonia M SM Solomos Nicole N Manavalan Poornima P Ragavendran Ashok A Ozsolak Fatih F Lee Jong Min JM Talkowski Michael E ME Gusella James F JF Macdonald Marcy E ME Park Peter J PJ Seong Ihn Sik IS
Human molecular genetics 20150108 9
The CAG repeat expansion in the Huntington's disease gene HTT extends a polyglutamine tract in mutant huntingtin that enhances its ability to facilitate polycomb repressive complex 2 (PRC2). To gain insight into this dominant gain of function, we mapped histone modifications genome-wide across an isogenic panel of mouse embryonic stem cell (ESC) and neuronal progenitor cell (NPC) lines, comparing the effects of Htt null and different size Htt CAG mutations. We found that Htt is required in ESC f ...[more]