Ontology highlight
ABSTRACT:
SUBMITTER: Yip PY
PROVIDER: S-EPMC4384220 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Translational lung cancer research 20150401 2
Non-small cell lung cancer (NSCLC) is a devastating disease with poor prognosis. Systemic chemotherapy has been the mainstay of treatment in advanced disease for many decades. Personalized targeted therapy such as epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) and crizotinib has significantly changed the treatment paradigm in NSCLC. The future success of development of molecular targeted therapy relies on the understanding of signal transduction pathways. The PI3K-Akt-mT ...[more]