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Robustness of target dose coverage to motion uncertainties for scanned carbon ion beam tracking therapy of moving tumors.

ABSTRACT: Beam tracking with scanned carbon ion radiotherapy achieves highly conformal target dose by steering carbon pencil beams to follow moving tumors using real-time magnetic deflection and range modulation. The purpose of this study was to evaluate the robustness of target dose coverage from beam tracking in light of positional uncertainties of moving targets and beams. To accomplish this, we simulated beam tracking for moving targets in both water phantoms and a sample of lung cancer patients using a research treatment planning system. We modeled various deviations from perfect tracking that could arise due to uncertainty in organ motion and limited precision of a scanned ion beam tracking system. We also investigated the effects of interfractional changes in organ motion on target dose coverage by simulating a complete course of treatment using serial (weekly) 4DCTs from six lung cancer patients. For perfect tracking of moving targets, we found that target dose coverage was high ([Formula: see text] was 94.8% for phantoms and 94.3% for lung cancer patients, respectively) but sensitive to changes in the phase of respiration at the start of treatment and to the respiratory period. Phase delays in tracking the moving targets led to large degradation of target dose coverage (up to 22% drop for a 15° delay). Sensitivity to technical uncertainties in beam tracking delivery was minimal for a lung cancer case. However, interfractional changes in anatomy and organ motion led to large decreases in target dose coverage (target coverage dropped approximately 8% due to anatomy and motion changes after 1?week). Our findings provide a better understand of the importance of each of these uncertainties for beam tracking with scanned carbon ion therapy and can be used to inform the design of future scanned ion beam tracking systems.

SUBMITTER: Eley JG

PROVIDER: S-EPMC4384336 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Robustness of target dose coverage to motion uncertainties for scanned carbon ion beam tracking therapy of moving tumors.

Eley John Gordon JG Newhauser Wayne David WD Richter Daniel D Lüchtenborg Robert R Saito Nami N Bert Christoph C

Physics in medicine and biology 20150204 4

Beam tracking with scanned carbon ion radiotherapy achieves highly conformal target dose by steering carbon pencil beams to follow moving tumors using real-time magnetic deflection and range modulation. The purpose of this study was to evaluate the robustness of target dose coverage from beam tracking in light of positional uncertainties of moving targets and beams. To accomplish this, we simulated beam tracking for moving targets in both water phantoms and a sample of lung cancer patients using ...[more]

PMID: 25650520

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Project description:PurposeThe characteristic of pulsed beam delivery for synchrotron-based carbon-ion radiotherapy has led to the emergence of many scanning scenarios in order to improve the treatment efficiency and accuracy of moving target volume. Here, we aim to evaluate a novel breathing guidance motion mitigation performance under different synchrotron flattop operation modes in carbon-ion radiotherapy.MethodsWith the use of twelve 4DCT datasets of lung cancer patients who had been treated with respiratory-gated carbon-ion pencil beam therapy, range-adapted internal target volume (raITV) plans were optimized. Under the fixed flattop with single-energy and extended flattop with multi-energy synchrotron operation modes, the 4D treatments with breathing guidance and free breathing-based gated phase-controlled rescanning (PCR) beam delivery were simulated. Dose metrics (D95 and D5-D95 in clinical target volume (CTV)) and treatment time of the resulting 4D plans were compared.ResultsThe two synchrotron operation modes provided different scanning dynamics. For the free breathing-based PCR method delivered in the extended flattop operation mode, the averaged CTV-D95 values were 90.4% ± 3.7%, 95.4% ± 1.7%, 96.9% ± 1.5%, 97.2% ± 1.5%, and 97.3% ± 1.5% for the 1-scanning, 2-PCR, 4-PCR, 6-PCR, and 8-PCR, respectively. For the breathing guidance-based PCR method delivered in the extended flattop mode, these values were 89.1% ± 4.0%, 97.0% ± 1.4%, 98.2% ± 0.7%, 98.6% ± 0.7%, and 98.9% ± 0.7%, respectively. However, CTV-D95 significantly increased to 98.5% ± 1.0% even with just 1-scanning breathing guidance-based fixed flattop operation mode (p < 0.01). Moreover, there was no significant difference in treatment time among the three technical combinations (p > 0.15).ConclusionsThe combination of the breathing guidance and PCR methods should be an alternative way for motion mitigation for the fixed flattop synchrotron operation mode. The target dose coverage and homogeneity could be further improved by the combination of the breathing guidance and PCR methods than the traditional PCR-only technology for the extended flattop synchrotron operation mode.

Project description:PurposeThe purpose of this study was to demonstrate high resolution optical luminescence sensing, referred to as Cherenkov excited luminescence scanning imaging (CELSI), could be achieved during a standard dynamic treatment plan for a whole breast radiotherapy geometry.MethodsThe treatment plan beams induce Cherenkov light within tissue, and this excitation projects through the beam trajectory across the medium, inducing luminescence where there can be molecular reporter. Broad beams generally produce higher signal but low spatial resolution, yet for dynamic plans the scanning of the multileaf collimator allows for a beam-narrowing strategy by recursively temporal differencing each of the Cherenkov images and associated luminescence images. Then reconstruction from each of these size-reduced beamlets defined by the differenced Cherenkov images provides a well-conditioned matrix inversion, where the spatial frequencies are limited by the higher signal-to-noise ratio beamlets. A built-in stepwise convergence relies on stepwise beam size reduction, which is associated with a widening of the bandwidth of Cherenkov spatial frequency and resultant increase in spatial resolution. For the phantom experiments, europium nanoparticles were used as luminescent probes and embedded at depths ranging from 3 to 8 mm. An intensity modulated radiotherapy (IMRT) plan was used to test this.ResultsThe Cherenkov images spatially guided where the luminescence was measured from, providing high lateral resolution, and iterative reconstruction convergence showed that optimization of the initial and stopping beamlet widths could be achieved with 15 and 4.5 mm, respectively, using a luminescence imaging frame rate of 5/s. With the IMRT breast plan, the original lateral resolution was improved 2X, that is, 0.08-0.24 mm for target depths of 3-8 mm. In comparison, a dynamic wedge (DW) plan showed an inferior image fidelity, with relative contrast recovery decreasing from 0.86 to 0.79. The methodology was applied to a three-dimensional dataset to reconstruct Cherenkov excited luminescence intensity distributions showing volumetric recovery of a 0.5 mm diameter object composed of 0.5 μM luminescent microbeads.ConclusionsHigh resolution CELSI was achieved with a clinical breast external beam radiotherapy (EBRT) plan. It is anticipated that this method can allow visualization and localization for luminescence/fluorescence tagged vasculature, lymph nodes, or superficial tagged regions with most dynamic treatment plans.

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Robustness of target dose coverage to motion uncertainties for scanned carbon ion beam tracking therapy of moving tumors.

Publications

Robustness of target dose coverage to motion uncertainties for scanned carbon ion beam tracking therapy of moving tumors.

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