Crystal structure of azilsartan methyl ester ethyl acetate hemisolvate.

ABSTRACT: The title compound, C26H22N4O5 (systematic name: methyl 2-eth-oxy-1-{4-[2-(5-oxo-4,5-di-hydro-1,2,4-oxa-diazol-3-yl)phenyl]benz-yl}-1H-1,3-benzo-diazole-7-carboxyl-ate ethyl acetate hemisolvate), was obtained via cyclization of methyl (Z)-2-eth-oxy-1-{(2'-(N'-hy-droxy-carbamimido-yl)-[1,1'-biphen-yl]-4-yl)meth-yl}-1H-benzo[d]imidazole-7-carboxyl-ate with diphen-yl carbonate. There are two independent mol-ecules (A and B) with different conformations and an ethyl acetate solvent mol-ecule in the asymmetric unit. In mol-ecule A, the dihedral angle between the benzene ring and its attached oxa-diazole ring is 59.36?(17); the dihedral angle between the benzene rings is 43.89?(15) and that between the benzene ring and its attached imidazole ring system is 80.06?(11)°. The corres-ponding dihedral angles in mol-ecule B are 58.45?(18), 50.73?(16) and 85.37?(10)°, respectively. The C-O-C-Cm (m = meth-yl) torsion angles for the eth-oxy side chains attached to the imidazole rings in mol-ecules A and B are 93.9?(3) and -174.6?(3)°, respectively. In the crystal, the components are linked by N-H?N and C-H?O hydrogen bonds, generating a three-dimensional network. Aromatic ?-? stacking inter-actions [shortest centroid-centroid separation = 3.536?(3)Å] are also observed.

SUBMITTER: Li Z 

PROVIDER: S-EPMC4384622 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature