Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC4384635 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Wang Qi Q Vogan Erik M EM Nocka Laura M LM Rosen Connor E CE Zorn Julie A JA Harrison Stephen C SC Kuriyan John J
eLife 20150220
Bruton's tyrosine kinase (Btk), a Tec-family tyrosine kinase, is essential for B-cell function. We present crystallographic and biochemical analyses of Btk, which together reveal molecular details of its autoinhibition and activation. Autoinhibited Btk adopts a compact conformation like that of inactive c-Src and c-Abl. A lipid-binding PH-TH module, unique to Tec kinases, acts in conjunction with the SH2 and SH3 domains to stabilize the inactive conformation. In addition to the expected activati ...[more]