Ontology highlight
ABSTRACT:
SUBMITTER: Howell M
PROVIDER: S-EPMC4384738 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
The Journal of cell biology 20150323 7
We previously identified Waf1 Cip1 stabilizing protein 39 (WISp39) as a binding partner for heat shock protein 90 (Hsp90). We now report that WISp39 has an essential function in the control of directed cell migration, which requires WISp39 interaction with Hsp90. WISp39 knockdown (KD) resulted in the loss of directional motility of mammalian cells and profound changes in cell morphology, including the loss of a single leading edge. WISp39 binds Coronin 1B, known to regulate the Arp2/3 complex an ...[more]