What is the utility of biomarkers for assessing the pathophysiology of hip osteoarthritis? A systematic review.

ABSTRACT:

Background

Innovations in biologics offer great promise in the treatment of patients with orthopaedic conditions and in advancing our ability to monitor underlying disease pathophysiology. Our understanding of the pathophysiology of hip osteoarthritis (OA) has improved significantly in the last decade. Femoroacetabular impingement (FAI) and hip dysplasia are increasingly recognized and treated as forms of prearthritic hip disease, yet the inability of radiographic and MR imaging to identify patients before the onset of irreversible articular cartilage injury limits their use for early diagnosis and treatment of patients with these conditions. Molecular biomarkers, as objectively measureable indicators of the pathophysiology of hip OA, have the potential to improve diagnosis, diseas

SUBMITTER: Nepple JJ 

PROVIDER: S-EPMC4385333 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature