Convergent transcriptional specializations in the brains of humans and song-learning birds.
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ABSTRACT:
SUBMITTER: Pfenning AR
PROVIDER: S-EPMC4385736 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Convergent transcriptional specializations in the brains of humans and song-learning birds.
Pfenning Andreas R AR Hara Erina E Whitney Osceola O Rivas Miriam V MV Wang Rui R Roulhac Petra L PL Howard Jason T JT Wirthlin Morgan M Lovell Peter V PV Ganapathy Ganeshkumar G Mouncastle Jacquelyn J Moseley M Arthur MA Thompson J Will JW Soderblom Erik J EJ Iriki Atsushi A Kato Masaki M Gilbert M Thomas P MT Zhang Guojie G Bakken Trygve T Bongaarts Angie A Bernard Amy A Lein Ed E Mello Claudio V CV Hartemink Alexander J AJ Jarvis Erich D ED
Science (New York, N.Y.) 20141201 6215
Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified convergent gene expression specializations in specific song and speech brain regions of avian vocal learners and humans. The strongest shared profiles relate bird motor and striatal song-learning nucl ...[more]
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