Mesenchymal stem cells are resistant to carbon ion radiotherapy.
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ABSTRACT:
SUBMITTER: Nicolay NH
PROVIDER: S-EPMC4385837 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Mesenchymal stem cells are resistant to carbon ion radiotherapy.
Nicolay Nils H NH Liang Yingying Y Lopez Perez Ramon R Bostel Tilman T Trinh Thuy T Sisombath Sonevisay S Weber Klaus-Josef KJ Ho Anthony D AD Debus Jürgen J Saffrich Rainer R Huber Peter E PE
Oncotarget 20150201 4
Mesenchymal stem cells (MSCs) participate in regeneration of tissues damaged by ionizing radiation. However, radiation can damage MSCs themselves. Here we show that cellular morphology, adhesion and migration abilities were not measurably altered by photon or carbon ion irradiation. The potential for differentiation was unaffected by either form of radiation, and established MSC surface markers were found to be stably expressed irrespective of radiation treatment. MSCs were able to efficiently r ...[more]
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