Ontology highlight
ABSTRACT:
SUBMITTER: Bu F
PROVIDER: S-EPMC4385840 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Bu Fangfang F Liu Xing X Li Jingjing J Chen Shukun S Tong Xin X Ma Chunsheng C Mao Hui H Pan Fei F Li Xiaoyan X Chen Bo B Xu Liyan L Li Enmin E Kou Geng G Han Jun J Guo Shangjing S Zhao Jian J Guo Yajun Y
Oncotarget 20150201 4
TGF-β1, a potent EMT (epithelial-mesenchymal transition) inducer present in the tumor microenvironment, is involved in the metastasis and progression of various carcinomas, including esophageal squamous cell carcinoma (ESCC). TIP30 (30kDa HIV-1 Tat interacting protein) is a putative tumor metastasis suppressor. Here, we found TIP30 was decreased in cells undergoing EMT induced by TGF-β1, an occurrence that was related to promoter hypermethylation. TGF-β1 induced TIP30 hypermethylation via increa ...[more]