Ontology highlight
ABSTRACT:
SUBMITTER: Takayama K
PROVIDER: S-EPMC4385850 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Takayama Ken-ichi K Suzuki Takashi T Tsutsumi Shuichi S Fujimura Tetsuya T Urano Tomohiko T Takahashi Satoru S Homma Yukio Y Aburatani Hiroyuki H Inoue Satoshi S
Oncotarget 20150201 4
Androgen receptor (AR) signaling is essential for the development of prostate cancer. Here, we report that runt-related transcription factor (RUNX1) could be a key molecule for the androgen-dependence of prostate cancer. We found RUNX1 is a target of AR and regulated positively by androgen. Our RUNX1 ChIP-seq analysis indicated that RUNX1 is recruited to AR binding sites by interacting with AR. In androgen-dependent cancer, loss of RUNX1 impairs AR-dependent transcription and cell growth. The RU ...[more]