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Gene expression network analysis reveals new transcriptional regulators as novel factors in human ischemic cardiomyopathy.

ABSTRACT: Ischemic cardiomyopathy (ICM) is characterized by transcriptomic changes that alter cellular processes leading to decreased cardiac output. Because the molecular network of ICM is largely unknown, the aim of this study was to characterize the role of new transcriptional regulators in the molecular mechanisms underlying the responses to ischemia.Myocardial tissue explants from ICM patients and control (CNT) subjects were analyzed by RNA-Sequencing (RNA-Seq) and quantitative Real-Time PCR.Enrichment analysis of the ICM transcriptomic profile allowed the characterization of novel master regulators. We found that the expression of the transcriptional regulators SP100 (-1.5-fold, p?

SUBMITTER: Herrer I

PROVIDER: S-EPMC4386080 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Gene expression network analysis reveals new transcriptional regulators as novel factors in human ischemic cardiomyopathy.

Herrer Isabel I Roselló-Lletí Esther E Ortega Ana A Tarazón Estefanía E Molina-Navarro María Micaela MM Triviño Juan Carlos JC Martínez-Dolz Luis L Almenar Luis L Lago Francisca F Sánchez-Lázaro Ignacio I González-Juanatey José Ramón JR Salvador Antonio A Portolés Manuel M Rivera Miguel M

BMC medical genomics 20150329

<h4>Background</h4>Ischemic cardiomyopathy (ICM) is characterized by transcriptomic changes that alter cellular processes leading to decreased cardiac output. Because the molecular network of ICM is largely unknown, the aim of this study was to characterize the role of new transcriptional regulators in the molecular mechanisms underlying the responses to ischemia.<h4>Methods</h4>Myocardial tissue explants from ICM patients and control (CNT) subjects were analyzed by RNA-Sequencing (RNA-Seq) and ...[more]

PMID: 25884818

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