Dataset Information

Vascular calcification in patients with nondialysis CKD over 3 years.

ABSTRACT:

Background and objectives

Vascular calcification (VC) is common in CKD, but little is known about its prognostic effect on patients with nondialysis CKD. The prevalence of VC and its ability to predict death, time to hospitalization, and renal progression were assessed.

Design, setting, participants, & measurements

The Study of Mineral and Bone Disorders in CKD in Spain is a prospective, observational, 3-year follow-up study of 742 patients with nondialysis CKD stages 3-5 from 39 centers in Spain from April to May 2009. VC was assessed using Adragao (AS; x-ray pelvis and hands) and Kauppila (KS; x-ray lateral lumbar spine) scores from 572 and 568 patients, respectively. The primary end point was death. Secondary outcomes were hospital admissions and appearance of a combined renal end point (beginning of dialysis or drop >30% in eGFR). Factors related to VC were assessed by logistic regression analysis. Survival analysis was assessed by Cox proportional models.

Results

VC was present in 79% of patients and prominent in 47% (AS?3 or KS>6). Age (odds ratio [OR], 1.05; 95% confidence interval [95% CI], 1.02 to 1.07; P<0.001), phosphorous (OR, 1.68; 95% CI, 1.28 to 2.20; P<0.001), and diabetes (OR, 2.11; 95% CI, 1.32 to 3.35; P=0.002) were independently related to AS?3. After a median follow-up of 35 months (interquartile range=17-36), there were 70 deaths (10%). After multivariate adjustment for age, smoking, diabetes, comorbidity, renal function, and level of phosphorous, AS?3 but not KS>6 was independently associated with all-cause (hazard ratio [HR], 2.07; 95% CI, 1.07 to 4.01; P=0.03) and cardiovascular (HR, 3.46; 95% CI, 1.27 to 9.45; P=0.02) mortality as well as a shorter hospitalization event-free period (HR, 1.14; 95% CI, 1.06 to 1.22; P<0.001). VC did not predict renal progression.

Conclusions

VC is highly prevalent in patients with CKD. VC assessment using AS independently predicts death and time to hospitalization. Therefore, it could be a useful index to identify patients with CKD at high risk of death and morbidity as previously reported in patients on dialysis.

SUBMITTER: Gorriz JL

PROVIDER: S-EPMC4386255 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Publications

Vascular calcification in patients with nondialysis CKD over 3 years.

Górriz José L JL Molina Pablo P Cerverón M Jesús MJ Vila Rocío R Bover Jordi J Nieto Javier J Barril Guillermina G Martínez-Castelao Alberto A Fernández Elvira E Escudero Verónica V Piñera Celestino C Adragao Teresa T Navarro-Gonzalez Juan F JF Molinero Luis M LM Castro-Alonso Cristina C Pallardó Luis M LM Jamal Sophie A SA

Clinical journal of the American Society of Nephrology : CJASN 20150313 4

<h4>Background and objectives</h4>Vascular calcification (VC) is common in CKD, but little is known about its prognostic effect on patients with nondialysis CKD. The prevalence of VC and its ability to predict death, time to hospitalization, and renal progression were assessed.<h4>Design, setting, participants, & measurements</h4>The Study of Mineral and Bone Disorders in CKD in Spain is a prospective, observational, 3-year follow-up study of 742 patients with nondialysis CKD stages 3-5 from 39 ...[more]

PMID: 25770175

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Dataset Information

Vascular calcification in patients with nondialysis CKD over 3 years.

Background and objectives

Design, setting, participants, & measurements

Results

Conclusions

Publications

Vascular calcification in patients with nondialysis CKD over 3 years.

Similar Datasets

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