Ontology highlight
ABSTRACT:
SUBMITTER: von Loeffelholz O
PROVIDER: S-EPMC4386334 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
von Loeffelholz Ottilie O Jiang Qiyang Q Ariosa Aileen A Karuppasamy Manikandan M Huard Karine K Berger Imre I Shan Shu-ou SO Schaffitzel Christiane C
Proceedings of the National Academy of Sciences of the United States of America 20150316 13
The signal recognition particle (SRP)-dependent pathway is essential for correct targeting of proteins to the membrane and subsequent insertion in the membrane or secretion. In Escherichia coli, the SRP and its receptor FtsY bind to ribosome-nascent chain complexes with signal sequences and undergo a series of distinct conformational changes, which ensures accurate timing and fidelity of protein targeting. Initial recruitment of the SRP receptor FtsY to the SRP-RNC complex results in GTP-indepen ...[more]