Ontology highlight
ABSTRACT:
SUBMITTER: Radovic-Moreno AF
PROVIDER: S-EPMC4386353 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Radovic-Moreno Aleksandar F AF Chernyak Natalia N Mader Christopher C CC Nallagatla Subbarao S Kang Richard S RS Hao Liangliang L Walker David A DA Halo Tiffany L TL Merkel Timothy J TJ Rische Clayton H CH Anantatmula Sagar S Burkhart Merideth M Mirkin Chad A CA Gryaznov Sergei M SM
Proceedings of the National Academy of Sciences of the United States of America 20150316 13
Immunomodulatory nucleic acids have extraordinary promise for treating disease, yet clinical progress has been limited by a lack of tools to safely increase activity in patients. Immunomodulatory nucleic acids act by agonizing or antagonizing endosomal toll-like receptors (TLR3, TLR7/8, and TLR9), proteins involved in innate immune signaling. Immunomodulatory spherical nucleic acids (SNAs) that stimulate (immunostimulatory, IS-SNA) or regulate (immunoregulatory, IR-SNA) immunity by engaging TLRs ...[more]