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Soft, curved electrode systems capable of integration on the auricle as a persistent brain-computer interface.

ABSTRACT: Recent advances in electrodes for noninvasive recording of electroencephalograms expand opportunities collecting such data for diagnosis of neurological disorders and brain-computer interfaces. Existing technologies, however, cannot be used effectively in continuous, uninterrupted modes for more than a few days due to irritation and irreversible degradation in the electrical and mechanical properties of the skin interface. Here we introduce a soft, foldable collection of electrodes in open, fractal mesh geometries that can mount directly and chronically on the complex surface topology of the auricle and the mastoid, to provide high-fidelity and long-term capture of electroencephalograms in ways that avoid any significant thermal, electrical, or mechanical loading of the skin. Experimental and computational studies establish the fundamental aspects of the bending and stretching mechanics that enable this type of intimate integration on the highly irregular and textured surfaces of the auricle. Cell level tests and thermal imaging studies establish the biocompatibility and wearability of such systems, with examples of high-quality measurements over periods of 2 wk with devices that remain mounted throughout daily activities including vigorous exercise, swimming, sleeping, and bathing. Demonstrations include a text speller with a steady-state visually evoked potential-based brain-computer interface and elicitation of an event-related potential (P300 wave).

SUBMITTER: Norton JJ

PROVIDER: S-EPMC4386388 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Soft, curved electrode systems capable of integration on the auricle as a persistent brain-computer interface.

Norton James J S JJ Lee Dong Sup DS Lee Jung Woo JW Lee Woosik W Kwon Ohjin O Won Phillip P Jung Sung-Young SY Cheng Huanyu H Jeong Jae-Woong JW Akce Abdullah A Umunna Stephen S Na Ilyoun I Kwon Yong Ho YH Wang Xiao-Qi XQ Liu ZhuangJian Z Paik Ungyu U Huang Yonggang Y Bretl Timothy T Yeo Woon-Hong WH Rogers John A JA

Proceedings of the National Academy of Sciences of the United States of America 20150316 13

Recent advances in electrodes for noninvasive recording of electroencephalograms expand opportunities collecting such data for diagnosis of neurological disorders and brain-computer interfaces. Existing technologies, however, cannot be used effectively in continuous, uninterrupted modes for more than a few days due to irritation and irreversible degradation in the electrical and mechanical properties of the skin interface. Here we introduce a soft, foldable collection of electrodes in open, frac ...[more]

PMID: 25775550

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Project description:Free communication is one of the cornerstones of modern civilisation. While manual keyboards currently allow us to interface with computers and manifest our thoughts, a next frontier is communication without manual input. Brain-computer interface (BCI) spellers often achieve this by decoding patterns of neural activity as users attend to flickering keyboard displays. To date, the highest performing spellers report typing rates of ~10.00 words/minute. While impressive, these rates are typically calculated for experienced users repetitively typing single phrases. It is therefore not clear whether naïve users are able to achieve such high rates with the added cognitive load of genuine free communication, which involves continuously generating and spelling novel words and phrases. In two experiments, we developed an open-source, high-performance, non-invasive BCI speller and examined its feasibility for free communication. The BCI speller required users to focus their visual attention on a flickering keyboard display, thereby producing unique cortical activity patterns for each key, which were decoded using filter-bank canonical correlation analysis. In Experiment 1, we tested whether seventeen naïve users could maintain rapid typing during prompted free word association. We found that information transfer rates were indeed slower during this free communication task than during typing of a cued character sequence. In Experiment 2, we further evaluated the speller's efficacy for free communication by developing a messaging interface, allowing users to engage in free conversation. The results showed that free communication was possible, but that information transfer was reduced by voluntary textual corrections and turn-taking during conversation. We evaluated a number of factors affecting the suitability of BCI spellers for free communication, and make specific recommendations for improving classification accuracy and usability. Overall, we found that developing a BCI speller for free communication requires a focus on usability over reduced character selection time, and as such, future performance appraisals should be based on genuine free communication scenarios.

Project description:Surface formulations of biophysical modeling problems offer attractive theoretical and computational properties. Numerical simulations based on these formulations usually begin with discretization of the surface under consideration; often, the surface is curved, possessing complicated structure and possibly singularities. Numerical simulations commonly are based on approximate, rather than exact, discretizations of these surfaces. To assess the strength of the dependence of simulation accuracy on the fidelity of surface representation, here methods were developed to model several important surface formulations using exact surface discretizations. Following and refining Zauhar's work [J. Comput.-Aided Mol. Des. 9, 149 (1995)], two classes of curved elements were defined that can exactly discretize the van der Waals, solvent-accessible, and solvent-excluded (molecular) surfaces. Numerical integration techniques are presented that can accurately evaluate nonsingular and singular integrals over these curved surfaces. After validating the exactness of the surface discretizations and demonstrating the correctness of the presented integration methods, a set of calculations are presented that compare the accuracy of approximate, planar-triangle-based discretizations and exact, curved-element-based simulations of surface-generalized-Born (sGB), surface-continuum van der Waals (scvdW), and boundary-element method (BEM) electrostatics problems. Results demonstrate that continuum electrostatic calculations with BEM using curved elements, piecewise-constant basis functions, and centroid collocation are nearly ten times more accurate than planar-triangle BEM for basis sets of comparable size. The sGB and scvdW calculations give exceptional accuracy even for the coarsest obtainable discretized surfaces. The extra accuracy is attributed to the exact representation of the solute-solvent interface; in contrast, commonly used planar-triangle discretizations can only offer improved approximations with increasing discretization and associated increases in computational resources. The results clearly demonstrate that the methods for approximate integration on an exact geometry are far more accurate than exact integration on an approximate geometry. A MATLAB implementation of the presented integration methods and sample data files containing curved-element discretizations of several small molecules are available online as supplemental material.

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Dataset Information

Soft, curved electrode systems capable of integration on the auricle as a persistent brain-computer interface.

Publications

Soft, curved electrode systems capable of integration on the auricle as a persistent brain-computer interface.

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