Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell KF
PROVIDER: S-EPMC4386410 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Mitchell Kaitlin F KF Zarnowski Robert R Sanchez Hiram H Edward Jessica A JA Reinicke Emily L EL Nett Jeniel E JE Mitchell Aaron P AP Andes David R DR
Proceedings of the National Academy of Sciences of the United States of America 20150313 13
Biofilms of the fungus Candida albicans produce extracellular matrix that confers such properties as adherence and drug resistance. Our prior studies indicate that the matrix is complex, with major polysaccharide constituents being α-mannan, β-1,6 glucan, and β-1,3 glucan. Here we implement genetic, biochemical, and pharmacological approaches to unravel the contributions of these three constituents to matrix structure and function. Interference with synthesis or export of any one polysaccharide ...[more]