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Modelling bladder cancer in mice: opportunities and challenges.

ABSTRACT: The prognosis and treatment of bladder cancer have improved little in the past 20 years. Bladder cancer remains a debilitating and often fatal disease, and is among the most costly cancers to treat. The generation of informative mouse models has the potential to improve our understanding of bladder cancer progression, as well as to affect its diagnosis and treatment. However, relatively few mouse models of bladder cancer have been described, and in particular, few that develop invasive cancer phenotypes. This Review focuses on opportunities for improving the landscape of mouse models of bladder cancer.

SUBMITTER: Kobayashi T

PROVIDER: S-EPMC4386904 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Modelling bladder cancer in mice: opportunities and challenges.

Kobayashi Takashi T Owczarek Tomasz B TB McKiernan James M JM Abate-Shen Cory C

Nature reviews. Cancer 20150101 1

The prognosis and treatment of bladder cancer have improved little in the past 20 years. Bladder cancer remains a debilitating and often fatal disease, and is among the most costly cancers to treat. The generation of informative mouse models has the potential to improve our understanding of bladder cancer progression, as well as to affect its diagnosis and treatment. However, relatively few mouse models of bladder cancer have been described, and in particular, few that develop invasive cancer ph ...[more]

PMID: 25533675

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