SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer.
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ABSTRACT:
SUBMITTER: Papadakis AI
PROVIDER: S-EPMC4387553 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer.
Papadakis Andreas I AI Sun Chong C Knijnenburg Theo A TA Xue Yibo Y Grernrum Wipawadee W Hölzel Michael M Nijkamp Wouter W Wessels Lodewyk F A LF Beijersbergen Roderick L RL Bernards Rene R Huang Sidong S
Cell research 20150206 4
Recurrent inactivating mutations in components of SWI/SNF chromatin-remodeling complexes have been identified across cancer types, supporting their roles as tumor suppressors in modulating oncogenic signaling pathways. We report here that SMARCE1 loss induces EGFR expression and confers resistance to MET and ALK inhibitors in non-small cell lung cancers (NSCLCs). We found that SMARCE1 binds to regulatory regions of the EGFR locus and suppresses EGFR transcription in part through regulating expre ...[more]
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