Ontology highlight
ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC4387561 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Sun Linchong L Song Libing L Wan Qianfen Q Wu Gongwei G Li Xinghua X Wang Yinghui Y Wang Jin J Liu Zhaoji Z Zhong Xiuying X He Xiaoping X Shen Shengqi S Pan Xin X Li Ailing A Wang Yulan Y Gao Ping P Tang Huiru H Zhang Huafeng H
Cell research 20150320 4
Cancer cells are known to undergo metabolic reprogramming to sustain survival and rapid proliferation, however, it remains to be fully elucidated how oncogenic lesions coordinate the metabolic switch under various stressed conditions. Here we show that deprivation of glucose or glutamine, two major nutrition sources for cancer cells, dramatically activated serine biosynthesis pathway (SSP) that was accompanied by elevated cMyc expression. We further identified that cMyc stimulated SSP activation ...[more]