Ontology highlight
ABSTRACT:
SUBMITTER: Bhatnagar P
PROVIDER: S-EPMC4387562 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Bhatnagar Pallav P Keefer Jeffrey R JR Casella James F JF Barron-Casella Emily A EA Bean Christopher J CJ Hooper Craig W CW Payne Amanda B AB Arking Dan E DE Debaun Michael R MR
Pediatric blood & cancer 20130515 10
The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well-known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta-analysis of data from the Silent Infarct Transfusion Trial (n = 456) and the Cooperative Study of Sickle Cell Disease (n = 764), demonstrated that baseline HbF levels were associ ...[more]