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Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia.

ABSTRACT: The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well-known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta-analysis of data from the Silent Infarct Transfusion Trial (n?=?456) and the Cooperative Study of Sickle Cell Disease (n?=?764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization (P-value?=?0.02).

SUBMITTER: Bhatnagar P

PROVIDER: S-EPMC4387562 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia.

Bhatnagar Pallav P Keefer Jeffrey R JR Casella James F JF Barron-Casella Emily A EA Bean Christopher J CJ Hooper Craig W CW Payne Amanda B AB Arking Dan E DE Debaun Michael R MR

Pediatric blood & cancer 20130515 10

The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well-known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta-analysis of data from the Silent Infarct Transfusion Trial (n = 456) and the Cooperative Study of Sickle Cell Disease (n = 764), demonstrated that baseline HbF levels were associ ...[more]

PMID: 23677903

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Normal saline bolus use in pediatric emergency departments is associated with poorer pain control in children with sickle cell anemia and vaso-occlusive pain.

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| S-EPMC3258348 | biostudies-literature

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