Dataset Information

Risk estimates for starting tobacco, alcohol, and other drug use in the United States: male-female differences and the possibility that 'limiting time with friends' is protective.

ABSTRACT: A specific facet of parental monitoring is known as 'limiting time with friends' (LTF). Here, we aim to learn whether LTF-associated differences in adolescent risk of starting to use tobacco, alcohol, and other drugs now might be as large as observed male-female risk differences.Data are from the US National Surveys on Drug Use and Health, with annual large scale nationally representative samples of community-dwelling civilian age 12 years and older, conducted 2002-2009. Focus is on 12-17-year-old participants, assessed via computerized self-interviews. Risk differences are estimated for all 12-17 year olds, males and females separately, and in relation to the LTF facet of parenting.Contingency table analyses disclose a female excess risk of initiating use of tobacco, alcohol, cocaine, opioids, and EMIRD, with male-female risk differences ranging from 0.1% (cocaine) to 1.6% (alcohol). LTF-associated risk differences were of similar magnitude for young people whose parents 'always' limit time with friends versus those with parents who are more relaxed about the LTF facet of parenting [e.g., RD=0.4% (cocaine); 1.5% (alcohol)].Not just for tobacco, but also for other drugs, there now is female excess risk of extra-medical drug use. Drug-by-drug, observed LTF-associated risk differences are about the same size as the female excess risk. This evidence provides a rationale to sustain focus on the LTF facet of parenting if the goal is to enhance prevention of precocious drug involvement and to delay its onset until later in the adolescent or adult years.

SUBMITTER: Seedall RB

PROVIDER: S-EPMC4388029 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Risk estimates for starting tobacco, alcohol, and other drug use in the United States: male-female differences and the possibility that 'limiting time with friends' is protective.

Seedall Ryan B RB Anthony James C JC

Drug and alcohol dependence 20130813 2

<h4>Background</h4>A specific facet of parental monitoring is known as 'limiting time with friends' (LTF). Here, we aim to learn whether LTF-associated differences in adolescent risk of starting to use tobacco, alcohol, and other drugs now might be as large as observed male-female risk differences.<h4>Methods</h4>Data are from the US National Surveys on Drug Use and Health, with annual large scale nationally representative samples of community-dwelling civilian age 12 years and older, conducted ...[more]

PMID: 24018318

Similar Datasets

Project description:BackgroundGlucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD). However, the probability of low semaglutide doses, an agonist with higher potency and affinity for GLP-1R, to attenuate alcohol-related responses in rodents and the underlying neuronal mechanisms is unknown.MethodsIn the intermittent access model, we examined the ability of semaglutide to decrease alcohol intake and block relapse-like drinking, as well as imaging the binding of fluorescently marked semaglutide to nucleus accumbens (NAc) in both male and female rats. The suppressive effect of semaglutide on alcohol-induced locomotor stimulation and in vivo dopamine release in NAc was tested in male mice. We evaluated effect of semaglutide on the in vivo release of dopamine metabolites (DOPAC and HVA) and gene expression of enzymes metabolising dopamine (MAOA and COMT) in male mice.FindingsIn male and female rats, acute and repeated semaglutide administration reduced alcohol intake and prevented relapse-like drinking. Moreover, fluorescently labelled semaglutide was detected in NAc of alcohol-drinking male and female rats. Further, semaglutide attenuated the ability of alcohol to cause hyperlocomotion and to elevate dopamine in NAc in male mice. As further shown in male mice, semaglutide enhanced DOPAC and HVA in NAc when alcohol was onboard and increased the gene expression of COMT and MAOA.InterpretationAltogether, this indicates that semaglutide reduces alcohol drinking behaviours, possibly via a reduction in alcohol-induced reward and NAc dependent mechanisms. As semaglutide also decreased body weight of alcohol-drinking rats of both sexes, upcoming clinical studies should test the plausibility that semaglutide reduces alcohol intake and body weight in overweight AUD patients.FundingSwedish Research Council (2019-01676), LUA/ALF (723941) from the Sahlgrenska University Hospital and the Swedish brain foundation.

Dataset Information

Risk estimates for starting tobacco, alcohol, and other drug use in the United States: male-female differences and the possibility that 'limiting time with friends' is protective.

Publications

Risk estimates for starting tobacco, alcohol, and other drug use in the United States: male-female differences and the possibility that 'limiting time with friends' is protective.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets