GATE validation of standard dual energy corrections in small animal SPECT-CT.
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ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC4388517 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
GATE validation of standard dual energy corrections in small animal SPECT-CT.
Lee Sanghyeb S Gregor Jens J Kennel Stephen J SJ Osborne Dustin R DR Wall Jonathan J
PloS one 20150407 4
This paper addresses 123I and 125I dual isotope SPECT imaging, which can be challenging because of spectrum overlap in the low energy spectrums of these isotopes. We first quantify the contribution of low-energy photons from each isotope using GATE-based Monte Carlo simulations for the MOBY mouse phantom. We then describe and analyze a simple, but effective method that uses the ratio of detected low and high energy 123I activity to separate the mixed low energy 123I and 125I activities. Performa ...[more]
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