Ontology highlight
ABSTRACT:
SUBMITTER: Bachas C
PROVIDER: S-EPMC4388534 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Bachas Costa C Schuurhuis Gerrit Jan GJ Zwaan C Michel CM van den Heuvel-Eibrink Marry M MM den Boer Monique L ML de Bont Eveline S J M ES Kwidama Zinia J ZJ Reinhardt Dirk D Creutzig Ursula U de Haas Valérie V Kaspers Gertjan J L GJ Cloos Jacqueline J
PloS one 20150407 4
Development of relapse remains a problem for further improvements in the survival of pediatric AML patients. While virtually all patients show a good response to initial treatment, more patients respond poorly when treated at relapse. The cellular characteristics of leukemic blast cells that allow survival of initial treatment, relapse development and subsequent resistance to salvage treatment remain largely elusive. Therefore, we studied if leukemic blasts at relapse biologically resemble their ...[more]