Ontology highlight
ABSTRACT:
SUBMITTER: Maddur MS
PROVIDER: S-EPMC4388556 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Maddur Mohan S MS Sharma Meenu M Hegde Pushpa P Stephen-Victor Emmanuel E Pulendran Bali B Kaveri Srini V SV Bayry Jagadeesh J
Nature communications 20140609
Dendritic cells (DCs) play a critical role in immune homeostasis by regulating the functions of various immune cells, including T and B cells. Notably, DCs also undergo education on reciprocal signalling by these immune cells and environmental factors. Various reports demonstrated that B cells have profound regulatory functions, although only few reports have explored the regulation of human DCs by B cells. Here we demonstrate that activated but not resting B cells induce maturation of DCs with ...[more]