Ontology highlight
ABSTRACT:
SUBMITTER: Benaud C
PROVIDER: S-EPMC4388614 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Benaud Christelle C Le Dez Gaëlle G Mironov Svetlana S Galli Federico F Reboutier David D Prigent Claude C
EMBO reports 20150223 4
Cytokinesis requires the formation of an actomyosin contractile ring between the two sets of sister chromatids. Annexin A2 is a calcium- and phospholipid-binding protein implicated in cortical actin remodeling. We report that annexin A2 accumulates at the equatorial cortex at the onset of cytokinesis and depletion of annexin A2 results in cytokinetic failure, due to a defective cleavage furrow assembly. In the absence of annexin A2, the small GTPase RhoA-which regulates cortical cytoskeletal rea ...[more]