Ontology highlight
ABSTRACT:
SUBMITTER: de la Mata M
PROVIDER: S-EPMC4388616 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
de la Mata Manuel M Gaidatzis Dimos D Vitanescu Mirela M Stadler Michael B MB Wentzel Corinna C Scheiffele Peter P Filipowicz Witold W Großhans Helge H
EMBO reports 20150227 4
MicroRNAs (miRNAs) regulate target mRNAs by silencing them. Reciprocally, however, target mRNAs can also modulate miRNA stability. Here, we uncover a remarkable efficacy of target RNA-directed miRNA degradation (TDMD) in rodent primary neurons. Coincident with degradation, and while still bound to Argonaute, targeted miRNAs are 3' terminally tailed and trimmed. Absolute quantification of both miRNAs and their decay-inducing targets suggests that neuronal TDMD is multiple turnover and does not in ...[more]