Ontology highlight
ABSTRACT:
SUBMITTER: Ramos AD
PROVIDER: S-EPMC4388801 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Ramos Alexander D AD Andersen Rebecca E RE Liu Siyuan John SJ Nowakowski Tomasz Jan TJ Hong Sung Jun SJ Gertz Caitlyn C Salinas Ryan D RD Zarabi Hosniya H Kriegstein Arnold R AR Lim Daniel A DA
Cell stem cell 20150319 4
While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify Pinky (Pnky) as a neural-specific lncRNA that regulates neurogenesis from NSCs in the embryonic and postnatal brain. In postnatal NSCs, Pnky knockdown potentiates neuronal lineage commitment and expands the transit-amplifying cell population, increasing neuron production several-fold. Pnky is evolutionarily conserved and expressed in NSCs of ...[more]