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Proline-Directed Androgen Receptor Phosphorylation.


ABSTRACT: The androgen receptor (AR) has been identified for decades and mediates essential steroid functions. Like most of biological molecules, AR functional activities are modulated by post-translational modifications. This review is focused on the reported activities and significance of AR phosphorylation, with particular emphasis on proline-directed serine/threonine phosphorylation that occurs predominantly on the receptor. The marked enrichment of AR phosphorylation in the most diverse N-terminal domain suggests that targeting AR phosphorylation can be synergistic to antagonizing the C-terminal domain by clinical antiandrogens.

SUBMITTER: Gao Y 

PROVIDER: S-EPMC4389684 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Proline-Directed Androgen Receptor Phosphorylation.

Gao Yanfei Y   Chen Shaoyong S  

Journal of molecular and genetic medicine : an international journal of biomedical research 20131001 3


The androgen receptor (AR) has been identified for decades and mediates essential steroid functions. Like most of biological molecules, AR functional activities are modulated by post-translational modifications. This review is focused on the reported activities and significance of AR phosphorylation, with particular emphasis on proline-directed serine/threonine phosphorylation that occurs predominantly on the receptor. The marked enrichment of AR phosphorylation in the most diverse N-terminal do  ...[more]

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