Interferon gamma polymorphisms and hepatitis B virus-related liver cirrhosis risk in a Chinese population.

ABSTRACT: BACKGROUND:Previous studies proved that interferon gamma (IFN-?) gene polymorphisms were associated with the risk of hepatitis B virus (HBV) infection. However, the association between IFN-? polymorphisms and HBV-related liver cirrhosis (HBV-LC) risk is still unclear. METHODS:IFN-? +874 T/A and +2109G/A genotypes were determined in 126 HBV-LC patients, 129 chronic hepatitis B(CHB) patients, and 173 early HBV infection controls using a sequence-specific primer-polymerase chain reaction and a polymerase chain reaction-restriction fragment length polymorphism, respectively. RESULTS:Significant associations were observed between +2109A/G polymorphisms and HBV-LC risk in the co-dominant model (GG vs. AA: OR?=?0.321, 95% CI?=?0.130-0.793, P?=?0.014), the allelic model (OR?=?0.565, 95% CI?=?0.388-0.825, P?=?0.003), the dominant model (OR?=?0.551, 95% CI?=?0.344-0.883, P?=?0.013), and the recessive model (OR?=?0.385, 95% CI?=?0.159-0.930, P?=?0.034). In addition, haplotype analysis indicated that the T(+874)G(+2109) haplotype significantly decreased the HBV-LC risk (OR?=?0.106, 95% CI?=?0.022-0.502, P?=?0.000), and A(+874)A(+2109) haplotype significantly increased the LC risk (OR?=?1.485, 95% CI?=?1.065-2.070, P?=?0.019). No significant associations were observed between IFN-? +874 T/A polymorphisms and HBV-LC risk, as well as the two single-nucleotide polymorphisms (SNPs) and CHB risk (P?>?0.05). CONCLUSIONS:Our observations suggested a significant association of IFN-? polymorphisms with HBV-LC risk in the Chinese population.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC4389711 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature