Ontology highlight
ABSTRACT:
SUBMITTER: Mahmood I
PROVIDER: S-EPMC4389735 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Mahmood Iftekhar I Staschen Carl-Michael CM Goteti Kosalaram K
The AAPS journal 20141002 6
The objective of this study is to evaluate the predictive performance of several models to predict drug clearance in children ≤5 years of age. Six models (allometric model (data-dependent exponent), fixed exponent of 0.75 model, maturation model, body weight-dependent model, segmented allometric model, and age-dependent exponent model) were evaluated in this study. From the literature, the clearance values for six drugs from neonates to adults were obtained. External data were used to evaluate t ...[more]