Ontology highlight
ABSTRACT:
SUBMITTER: Dos Santos Pereira JN
PROVIDER: S-EPMC4389740 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
The AAPS journal 20140826 6
Variations in influx transport at the blood-brain barrier might affect the concentration of psychotropic drugs at their site of action and as a consequence might alter therapy response. Furthermore, influx transporters in organs such as the gut, liver and kidney may influence absorption, distribution, and elimination. Here, we analyzed 30 commonly used psychotropic drugs using a parallel artificial membrane permeability assay. Amisulpride and sulpiride showed the lowest membrane permeability (P ...[more]