Ontology highlight
ABSTRACT:
SUBMITTER: Yoon JH
PROVIDER: S-EPMC4390267 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Yoon Jong Hyuk JH Kim Dayea D Jang Jin-Hyeok JH Ghim Jaewang J Park Soyeon S Song Parkyong P Kwon Yonghoon Y Kim Jaeyoon J Hwang Daehee D Bae Yoe-Sik YS Suh Pann-Ghill PG Berggren Per-Olof PO Ryu Sung Ho SH
Molecular & cellular proteomics : MCP 20150123 4
Elevated levels of the free fatty acid palmitate are found in the plasma of obese patients and induce insulin resistance. Skeletal muscle secretes myokines as extracellular signaling mediators in response to pathophysiological conditions. Here, we identified and characterized the skeletal muscle secretome in response to palmitate-induced insulin resistance. Using a quantitative proteomic approach, we identified 36 secretory proteins modulated by palmitate-induced insulin resistance. Bioinformati ...[more]