Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki M
PROVIDER: S-EPMC4390307 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Suzuki Masami M Chiwaki Fumiko F Sawada Yumi Y Ashikawa Maho M Aoyagi Kazuhiko K Fujita Takeshi T Yanagihara Kazuyoshi K Komatsu Masayuki M Narita Minoru M Suzuki Tsutomu T Nagase Hiroshi H Kushima Ryoji R Sakamoto Hiromi H Fukagawa Takeo T Katai Hitoshi H Nakagama Hitoshi H Yoshida Teruhiko T Uezono Yasuhito Y Sasaki Hiroki H
PloS one 20150408 4
The dormancy of tumor cells is a major problem in chemotherapy, since it limits the therapeutic efficacy of anti-tumor drugs that only target dividing cells. One potential way to overcome chemo-resistance is to "wake up" these dormant cells. Here we show that the opioid antagonist methylnaltrexone (MNTX) enhances the effect of docetaxel (Doc) by blocking a cell growth-suppressive pathway. We found that PENK, which encodes opioid growth factor (OGF) and suppresses cell growth, is predominantly ex ...[more]