A prokaryotic twist on argonaute function.
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ABSTRACT:
SUBMITTER: Willkomm S
PROVIDER: S-EPMC4390867 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
A prokaryotic twist on argonaute function.
Willkomm Sarah S Zander Adrian A Gust Alexander A Grohmann Dina D
Life (Basel, Switzerland) 20150216 1
Argonaute proteins can be found in all three domains of life. In eukaryotic organisms, Argonaute is, as the functional core of the RNA-silencing machinery, critically involved in the regulation of gene expression. Despite the mechanistic and structural similarities between archaeal, bacterial and eukaryotic Argonaute proteins, the biological function of bacterial and archaeal Argonautes has remained elusive. This review discusses new findings in the field that shed light on the structure and fun ...[more]
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